Linear And Whorled Nevoid Hypermelanosis: A Rare Familial Case Report

Linear and whorled nevoid hypermelanosis (LWNH), also known as ‘zebra-like pigmentation’ is characterized by linear and swirling streaks of hyperpigmentation along the Blaschko’slines without preceding inflammation and atrophy. It is mainly located on trunk and limbs. The hyperpigmentation may be present at birth or may develop by early childhood. Very rarely, familial cases have been described. Here, we are reporting one such rare case of familial LWNH in a 19-year-old female

Eat dirt and avoid atopy: the hygiene hypothesis revisited.

The explosive rise in the incidence of atopic diseases in the Western developed countries can be explained on the basis of the so-called "hygiene hypothesis". In short, it attributes the rising incidence of atopic dermatitis to reduced exposure to various childhood infections and bacterial endotoxins. Reduced exposure to dirt in the clean environment results in a skewed development of the immune system which results in an abnormal allergic response to various environmental allergens which are otherwise innocuous. This article reviews the historical aspects, epidemiological and immunological basis of the hygiene hypothesis and implications for Indian conditions.